Christina Applegate says she has 30 lesions on her brain amid MS battle: ‘Worst thing that’s happened to me’

“It sucks,” the “Anchorman” actress added. “I hate it so much. I’m so mad about it. You can’t overcome it.”

She also explained that she prefers to speak truthfully about her MS journey because she did not do so when she battled breast cancer. “Everything I was saying was a freaking lie,” she admitted.

“It was me trying to convince myself of something, and I think that did no service to anyone.”

Applegate underwent a double mastectomy in 2008, which removed her breast cancer. In 2017, she had her ovaries and fallopian tubes removed as a preventive measure against ovarian cancer, from which her cousin died.

Earlier this month, she opened up more about her daily life with MS during a chat with People. “Well, you pee … in your pants,” she candidly stated. “Because you probably can’t get to the bathroom in time. So yeah, diapers.”

On the bright side, she said she enjoys getting to park in handicapped spots and getting to board planes early when traveling.

In January, she made a surprise appearance at the Emmys and joked about her condition by calling out the audience for “totally shaming” her when they gave her a standing ovation. She also strolled onto the stage with attitude by using a cane that read, “FU MS.”

Applegate, who was nominated at the 2024 Emmys for outstanding lead actress in a comedy series for her role in “Dead to Me,” had previously claimed the 2023 SAG Awards would be her “last awards show as an actor.”

It’s unclear if she will make her way onto another awards show stage, but if there’s one thing fans can expect from Applegate, it’s that she will always keep it real about her diagnosis and use humor to cope.

“My humor shield keeps me OK, but of course, down on the insides, you feel the things and I do it to kind of deflect and then also make people not be scared to be around me,” the star explained during a 2022 episode of “The Kelly Clarkson Show.”

“You know, when people see me now as a disabled person, I want them to feel comfortable,” she added.

“That we can laugh about it.”